PTS helps customers to find technological solutions and provides GMP manufacturing. Polyamino acid technology is PEG-free, with reduced immunogenicity & allows for the tissue specific delivery of Nucleic Acids, Small Molecules or Proteins.
1- Multifunctionality: diversity and number of attachment sites or stimuli responsive groups through amino acid side chain. High cargo loadings and modulation of interactions with biological barriers
2- Chemical & Architectural versatility: introduce multiple orthogonal & functional groups displayed in different nanosized 3D arquitectures
3- Living polymerisation: C-N terminus groups, Telechelic binding sites
4- Chemical process yields a toolbox of architectures to further engineer drug delivery systems
Benefits
Drug delivery systems with versatile architecture and functionality specially suited to deliver Nucleic Acids, Small molecules and Biologics
Superior biodegradability and biocompatibility with low immunogenicity
High cargo loadings and improved bioavailability of your APIs
Modulation of interactions with biological barriers allowing to explore multiple administration routes to target specific tissues and organs
Reformulation or repositioning of APIs without chemical modification vs. API conjugation as New Chemical Entities (API-Polypeptide conjugates) for IP extension
Readily water-soluble with very simple (or no) formulation required